University of Florida Forensic Immunology Research Paper
Question Description
- Discuss the two types of infections that can result in microbes living inside cells, from which they then have to be eliminated by cell-mediated immune response. (2 points)
- What four types of receptors are needed for the initiation of T cell responses? (3 points)
- Explain how the TCR (T cell receptor) for antigen and the CD4 or CD8 co-receptor work together to recognize the complex of peptide antigens and MHC molecules on APCs. (3 points)
- It is thought that the differences in the clonal expansion of CD8+ T cells and CD4+ T cells could be attributed to the different functions the cells have. Discuss why you think the functions of the cells could impact their rate of clonal expansion. (3 points)
- Discuss the differences of TH1 cells and TH2 cells (type 1 helper T cells and type 2 helper T cells). (3 points)
- Discuss how T lymphocytes activate macrophages and how the macrophages eliminate phagocytosed microbes. (6 points)
- What role do perforins and granzymes play in the killing of target cells by cytolytic T lymphocytes (CTLs)? (2 points)
- How are the humoral immune responses initiated? Where in the body does this occur? (3 points)
- When does receptor cross-linking occur and what is the result? (4 points)
- How do helper T cells activate B-cells? Describe this in detail. (6 points)
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